Permethrin

Permethrin is a Synthetic Pyrethroid, it is not organic or made from flowers.

Pyrethroid Pesticides were developed as a synthetic version of the naturally occurring pesticide pyrethrin, which is found in chrysanthemums. They have been modified to increase their stability in the environment. Some synthetic pyrethroids are toxic to the nervous system.
http://www.epa.gov/pesticides/about/types.htm

Health Effects

The following information (Health Effects, Handling/Disposal, and Ingredients) is taken from the product label and/or the Material Safety Data Sheet (MSDS) prepared by the manufacturer. The National Library of Medicine does not evaluate information from the product label or the Material Safety Data Sheet.

Warning from
Product Label:
Warning: Keep Out of Reach of Children
Acute Health Effects: From MSDS:
Routes of Entry Acute Effects: Absorbed through skin. Inhalation.

Skin: Hazardous in case of skin contact (irritant, permeator). Harmful if absorbed through the skin. Direct contact may cause irritation and redness.
Eyes: Hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching.
Inhalation: Harmful if inhaled. May cause respiratory tract irritation.
Ingestion: Harmful if swallowed. Ingestion may cause severe gastric disturbances.

Toxicological Information
Toxicity to Animals: Permethrin
 
Chronic Health Effects: MSDS: Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.

 

Acute Health Effects: From MSDS
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of intoxication to permethrin may include hypersensitivity, tremors, diarrhea, etc.. Intoxication to solvents include dizziness, headache, nausea, narcosis, eye irritation, G.I. tract irritation, cardiac arrhythmia.
PRIMARY ROUTES OF ENTRY: Inhalation and dermal based on product form.
 
Chronic Health Effects: Chronic symptoms not known for this product.

From MSDS
SIGNS AND SYMPTOMS OF OVEREXPOSURE
Symptoms of intoxication to permethrin are hypersensitivity, tremors, diarrhea. Intoxication to solvents may cause dizziness, headache, nausea, narcosis, eye irritation, G.I. tract irritation, and cardiac arrhythmia in certain cases.
 

From MSDS
SIGNS AND SYMPTOMS OF OVEREXPOSURE
Symptoms of intoxication to permethrin are hypersensitivity, tremors, diarrhea. Intoxication to solvents may cause dizziness, headache, nausea, narcosis, eye irritation, G.I. tract irritation, and cardiac arrhythmia in certain cases.
PRIMARY ROUTE OF ENTRY Dermal/Eye: Yes; Oral: No; Inhalation: Yes

Skin Irritation: Moderately irritating to the skin
Eye Irritation: Not an eye irritant
Sensitizer: Weak sensitizer
 

Acute Health Effects: From MSDS:
IMMEDIATE CONCERNS: - MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN
- CAUSES EYE IRRITATION
- AVOID CONTACT WITH EYES, SKIN OR CLOTHING
- KEEP OUT OF REACH OF CHILDREN

POTENTIAL HEALTH EFFECTS

EYES: This substance is slightly irritating to the eyes. Eye contact may include discomfort, tearing, redness, swelling, and blurred vision.
SKIN: This substance is not expected to cause prolonged or significant skin irritation. May include redness, itching and swelling. If absorbed through the skin, this substance is considered practically non-toxic.
INGESTION: If swallowed, this substance is considered practically non-toxic.
INHALATION: This substance may be slightly toxic to internal organs if inhaled. The degree of injury will depend on the airborne concentration and duration of exposure. This substance may be irritating if inhaled.
 
Chronic Health Effects: MSDS: No information provided.
Carcinogenicity: MSDS:
Permethrin has been designated as a possible human carcinogen (Group C) by the U.S. EPA.
Acute Health Effects: From MSDS:
IMMEDIATE CONCERNS: HARMFUL IF SWALLOWED
CAUSES EYE IRRITATION
AVOID CONTACT WITH EYES, SKIN, OR CLOTHING
AVOID BREATHING DUST
KEEP OUT OF REACH OF CHILDREN

POTENTIAL HEALTH EFFECTS

EYES: Eye contact may cause discomfort, tearing, swelling, redness, and blurred vision.
SKIN: This substance is not expected to cause prolonged or significant skin irritation. If absorbed through the skin, this substance is considered practically non-toxic to internal organs.
INGESTION: Ingestion may cause irritation of the digestive tract which may include nausea, vomiting, and diarrhea. If swallowed, this substance is considered practically non-toxic to internal organs.
INHALATION: This substance is slightly toxic to internal organs if inhaled. The degree of injury will depend on the airborne concentration and duration of exposure. This substance may be irritating if inhaled. S
 
Chronic Health Effects: MSDS: No information provided.
Carcinogenicity: MSDS:
Permethrin, one of the active ingredients in this product, has been designated as a possible human carcinogen (Group C) by IARC.
Acute Health Effects: From MSDS:
IMMEDIATE CONCERNS:
HARMFUL IF SWALLOWED
CAUSES EYE IRRITATION
AVOID CONTACT WITH EYES, SKIN, OR CLOTHING
AVOID BREATHING DUST
KEEP OUT OF REACH OF CHILDREN

POTENTIAL HEALTH EFFECTS
EYES: Eye contact may cause discomfort, tearing, swelling, redness, and blurred vision.
SKIN: This substance is not expected to cause prolonged or significant skin irritation. If absorbed through the skin, this substance is considered practically non-toxic to internal organs.
INGESTION: Ingestion may cause irritation of the digestive tract which may include nausea, vomiting, and diarrhea. If swallowed, this substance is considered practically non-toxic to internal organs.
INHALATION: This substance is slightly toxic to internal organs if inhaled. The degree of injury will depend on the airborne concentration and duration of exposure. This substance may be irritating if inhaled.
 
Chronic Health Effects: MSDS: No evidence of chronic effects.
Carcinogenicity: MSDS: IARC: Permethrin, one of the active ingredients in this product, has been designated as a possible human carcinogen (Group C) by the U.S. EPA.
Acute Health Effects: From MSDS

PRIMARY ROUTES OF ENTRY: Acute and chronic effects from overexposure may result from inhalation and ingestion.

ACUTE EFFECTS FROM OVEREXPOSURE: Data available to date on human exposure suggests that permethrin does not produce skin sensations (feelings of numbing and tingling), although other pyrethroids have been known to
cause these reactions. If they occur, these sensations subside and disappear within a few hours. Large, toxic doses administered to laboratory animals have produced central nervous system effects with symptoms that include
diarrhea, salivation, bloody nose, tremors and intermittent convulsions. Overexposure of animals to permethrin via inhalation has also produced hyperactivity and hypersensitivity.

MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: None presently known
 
Chronic Health Effects: MSDS: CHRONIC EFFECTS FROM OVEREXPOSURE: In studies with laboratory animals, permethrin did not cause reproductive toxicity or teratogenicity. Analysis of chronic feeding studies in both mice and rats with permethrin resulted in the conclusion that permethrin's potential for induction of oncogenicity in experimental animals is low and that the likelihood of oncogenic effects in humans is nonexistent or extremely low. Long terms feeding studies
in animals resulted in increased liver and kidney weights, induction of the liver microsomal drug metabolizing enzyme system and histopathological changes in the lungs and liver. An overall lack of genotoxicity has been demonstrated in mutagenicity testing with permethrin.
 

 

 

 

For more information on West Nile Virus and mosquito management see The Truth About Mosquitoes, Pesticides, and West Nile Virus.

Permethrin Public Comment US EPA September 26, 2006
http://cfpub.epa.gov/pesticides/comments.cfm
http://www.regulations.gov/fdmspublic/component/main

Docket Information
Docket ID   EPA-HQ-OPP-2004-0385
Long Title   Permethrin; Notice of Availability of Risk Assessments and Opening of Docket
 Document Information
Document ID  EPA-HQ-OPP-2004-0385-0059
Document Title  Permethrin Reregistration Eligibility Decision; Notice of Availability
How to Comment  Submit your comments, identified by docket identification (ID) number EPA-HQ-OPP-2004-0385, by one of the following methods:
•  Federal eRulemaking Portal: http://www.regulations.gov. Follow theon-line instructions for submitting comments.
•  Mail: Office of Pesticide Programs (OPP) Regulatory Public Docket (7502P), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001.
•  Delivery: OPP Regulatory Public Docket (7502P), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Building), 2777 S. Crystal Drive, Arlington, VA. Deliveries are only accepted during the Docket"s normal hours of operation (8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays). Special arrangements should be made for deliveries of boxed information. The Docket telephone number is (703) 305-5805. Instructions: Direct your comments to docket ID number EPA-HQ-OPP- 2004-0385. EPA"s policy is that all comments received will be included in the docket without change and may be made available on-line at http://www.regulations.gov, including any personal information provided, unless the comment includes information claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through regulations.gov or e- mail. The Federal regulations.gov website is an anonymous access system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through regulations.gov, your e-mail address will be automatically captured and included as part of the comment that is placed in the docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD-ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form of encryption, and be free of any defects or viruses. Docket: All documents in the docket are listed in the docket index. Although listed in the index, some information is not publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other material, such as copyrighted material, is not placed on the Internet and will be publicly available only in hard copy form. Publicly available docket materials are available either in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Building), 2777 S. Crystal Drive, Arlington, VA. The hours of operation of this Docket Facility are from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. The Docket telephone number is (703) 305-5805.

 

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